Kai Ling(凌恺)

Ph.D student in CS

Purdue University

Studying all aspect of Computational Biology

Especially in protein structure prediction and structure modeling

Undergraduated Student Majored in CS

Huazhong University of Science and Technology

Studying technologies both in software and hardware

Research Assistant

Kihara Computational Biology Lab | Purdue

Advisor: Daisuke Kihara, Professor of Biological Sciences and Computer Science, Purdue

Distance-AF Multimer Project (Project Leader)

• Pioneered Distance-AF Multimer, a revolutionary deep learning framework that dramatically enhances protein complex structure prediction

• Strategically integrated experimental distance constraints with AlphaFold2-Multimer, solving previously intractable molecular modeling challenges

• Engineered innovative solutions through distance range constraints and conformer sampling strategies

• Delivered remarkable 60Å RMSD improvement in challenging quaternary structure predictions, enabling new opportunities for drug discovery

Daq Refine Web Tool Project (Project Leader)

• Built a full-stack web application for refining protein models from cryo-EM data using React.js frontend and Python/Flask backend

• Designed and implemented RESTful APIs that handle complex multi-chain protein models with up to 50,000 atoms

• Deployed application on AWS using Docker containers and implemented CI/CD pipeline for automated testing and deployment

• Engineered distributed computing framework that reduced processing time by 40% through parallel execution of refinement algorithms

Vice Monitor

General Committee Office in Center of Art Education, HUST

• Hosted bi-weekly class meetings

• Designed organized more than 10 events and activities, including tours, contests and discussions

• Organized the Excellent League Activity and won the first prize in school (10 out of 70 groups)

• Recognized for the Outstanding Student Leadership in HUST, given to 10 students out of 120